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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Is the ingestion of fluoride an immunosuppressive practice?

1991 | Medical Hypotheses | Sutton PRN. | 35:1-3.
Introduction In 1987, Moolenburgh (1) stated: 'I am absolutely convinced that fluoride is an immune suppressive substance.' He came to that conclusion following double-blind clinical tests which showed that there were many adverse reactions resulting from drinking fluoridated water. In 1987, Sutton (2) advanced the hypothesis that, as a result of the normal resorption of bone containing a high concentration of fluoride (which forms in those who habitually drink fluoridated water) (3), the rele

Time trends for bone and joint cancers and osteosarcomas in the Surveillance, Epidemiology and End Results (SEER) Program

1991 | Public Health Service; Review of Fluoride: Risks and Benefits | Hoover RN, Devesa S, Cantor K, Fraumeni JF. | Appendix F; p. F1-F7
At the request of the Committee, we have enclosed a brief description of the time trends for bone and joint cancers and for osteosarcomas in the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute (NCI), and the relationship of these trends to fluoridation of drinking water supplies. The SEER Program, begun in 1973, is a group of population-based cancer registries that covers approximately 10% of the U.S. population. In contrast to our main report which foc

Red blood cell glucose metabolism in human chronic fluoride toxicity

1991 | Bulletin of Environmental Contamination and Toxicology | Saralakumari D, Rao PR. | 47:834-39.
Fluoride is a well known inhibitor of many enzyme systems in vitro (Shahed etal. 1979; Messer 1984). The most widely studied classic example of fluoride inhibition is its potent inhibition of glycolysis, specifically its action on the enzyme enolase (Warburg and Christian 1941; Shearer and Suttie 1970; Repaske and Suttie 1979; Shahed et al. 1979). Despite the plethora of in vitro studies on the effects of fluoride on the enzyme activity, there is a paucity of information concerning the in vivo m