4. Discussion
... the numbers of Nissl bodies in neurons in the hippocampus and cortex of
brains from both adult rats and their pups with fluorosis were lowered.
Such reduction in Nissl bodies, showing large granular bodies consisting
of rough endoplasmic reticulum with rosettes of free ribosomes
carrying out protein synthesis, indicates injury of neurons [23].
In cerebral cortex of the rats, treated with 100 ppm of sodium fluoride, there was disorganization of granular cell layer. The granule cells were accumulated in the form of clumps. Some pyramidal neurons showed chromatolysis (Fig. 2) and were shrunken with vacuolation around them (Fig. 4). The nuclei of some pyramidal neurons were eccentric in neuroplasm and others were showing necrosis. Some granule cells were swollen in shape and size (Fig. 5).
... In rats treated with 200 ppm of sodium flu
