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Effect of fluoride on brain of albino-rabbit – An experimental study.

From Table 1: Gross and brain cyto-architecture changes of experimental animals at the end of 16 weeks. Changes in Brain Cytoarchitecture: The neurones lost their angular or pyramidal shape and acquired a plump, ovoid, rounded, or characteristic "ballooned" appearance (Figure 1). The nucleus was displaced to the periphery or axonal base and was shrunken, pyknotic, or absent. Reduction in the number of Purkinje neurones and in some areas even complete loss of neurones. Pyramidal neurones exhib