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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Clofibrate, a Peroxisome Proliferator-Activated Receptor-Alpha (PPAR?) Agonist, and Its Molecular Mechanisms of Action against Sodium Fluoride-Induced Toxicity.

April 24, 2021 | Biological Trace Element Research | Oyagbemi AA, Adejumobi OA, Jarikre TA, Ajani OS, Asenuga ER, Gbadamosi IT, Adedapo ADA, Aro AO, Ogunpolu BS, Hassan FO, Falayi OO, Ogunmiluyi IO, Omobowale TO, Arojojoye OA, Ola-Davies OE, Saba AB, Adedapo AA, Emikpe BO, Oyeyemi MO, Nkadimeng SM, McGaw LJ, Kayoka-Kabongo PN, Oguntibeju OO, Yakubu MA. | [Epub ahead of print]

Probiotic alleviate fluoride-induced memory impairment by reconstructing gut microbiota in mice.

March 30, 2021 | Ecotoxicology and Environmental Safety | Xin J, Wang H, Sun N, Bughio S, Zeng D, Li L, Wang Y, Khalique A, Zeng Y, Pan K, Jing B, Ma H, Bai Y, Ni X. | 215:112108.
1. Introduction Fluoride is a widespread environmental pollution, and groundwater is the major source of exposure in which the fluoride concentration can be as high as 35 ppm (Petrone et al., 2013). Fluorosis induced by geological origin is a serious public health concern in 28 nations particularly in India and China (Rafique et al., 2015). In India, 230 districts of 20 states are at risk of a high level of fluoride in drinking water (Srivastava and Flora, 2020). In China, almost all the provi

Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice

March 2009 | Anesthesiology | Satomoto M, Satoh Y, Terui K, Miyao H, Takishima K, Ito M, Imaki J. | 110(3):628-37.
References 1. Bayer SA, Altman J, Russo RJ, Zhang X: Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology 1993; 14:83–144. 2. Rice D, Barone S Jr: Critical periods of vulnerability for the developing nervous system: Evidence from humans and animal models. Environ Health Perspect 2000; 108:511–33. 3. Olney JW, Tenkova T, Dikranian K, Qin YQ, Labruyere J, Ikonomidou C: Ethanol-induced apoptotic neurodegeneration in the

Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.

March 12, 2021 | BJA (British Journal of Anaesthesia) | Lee JR, Joseph B, Hofacer RD, Upton B, Lee SY, Ewing L, Zhang B, Danzer SC, Loepke AW. | [Epub ahead of print]
References Lin E.P., Lee J.R., Lee C.S., Deng M., Loepke A.W. Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies. Neurotoxicol Teratol. 2017; 60: 117-128. PubMed Jevtovic-Todorovic V., Olney J.W. PRO: anesthesia-induced developmental neuroapoptosis: status of the evidence. Anesth Analg. 2008; 106: 1659-1663. PubMed Loepke A.W. McGowan Jr., F.X. Soriano S.G. CON: the toxic effects of anestheti

National Toxicology Program Systematic literature review of animal studies.

July 2016 | | National Toxicology Program |
Official citation: NTP (National Toxicology Program). 2016. Systematic Literature Review on the Effects of Fluoride on Learning and Memory in Animal Studies. NTP Research Report 1. Research Triangle Park, NC: National Toxicology Program. Conclusion (page 59): Very few studies assessed learning and memory effects in experimental animals (rats and mice) at  exposure levels near 0.7 parts per million, the recommended level for community water  fluoridation in the United States. At concentration