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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Topical fluorides: effects on physiologic and biochemical processes

May 1987 | Journal of Dental Research | Whitford GM, Allmann DW, Shahed AR. | 66(5):1072-8.
The mechanism underlying [fluoride-induced] hyperglycemia could include any or all of the following factors: (a) an increase in cellular cAMP followed by an increase in glycogenolysis in fed animals or, in fasted animals, gluconeogenesis; (b) an increase in plasma epinephrine levels; (c) an increase in plasma gluccocorticoid concentrations; and/or (d) a decrease in plasma insulin levels. Additional research is needed to determine which of these possible mechanisms is/are responsible for inducing