Previous behavioural studies shows that excessive exposure of fluoride caused diminished intelligent quotient in children compared to the normal children (Wang et al., 2004) and sodium fluoride intoxicated rat exerted loss of memory and learning disability (Yaning et al., 2005). In the present study postnatal rats aged day 21 and day 30 demonstrated loss of memory, learning inability and there was a considerable increase in the goal achieve latency period in NaF treated group when compared to th
At 3 months in the cerebellum, most of the neurons had normal cell structures and only a few Purkinje cell irregularities were notable, such as cell swelling and balloon-like cells in rats subjected to 30 ppm fluoride. In the cerebrum and hippocampus, no neuronal damage
was observed in rats exposed to 30 ppm fluoride. However, neurodegenerative changes were seen in the neurons of the rats exposed to 100 ppm fluoride. In the cerebellum, cell structure irregularities and Purkinje cell swelling we
