A marked fall (p < 0.01) in the testosterone production was recorded at a fluoride concentration of 100 ppm and testosterone synthesis was maximally inhibited (p < 0.01) at 200 ppm. There was a noticeable, though marginal, inhibition in testosterone synthesis even at 10 ppm fluoride concentration. From 1 ppm to 200 ppm, the degree of inhibition of testosterone synthesis seems to be dependent on fluoride concentration.
Crippling fluorosis... is characterized by dense bones, exostoses, neurologic complications due to bony overgrowth, osteoarthritis, and ligamentous calcification.
... new bone formed under the stimulus of fluoride administration may exhibit various degrees of osteosclerosis, osteoporosis, osteomalacia, and architectural disorganization. Of these manifestations, only osteosclerosis increases bone strength. When fluoride is used therapeutically, therefore, it is obvious that conditions must be
Results
Of the 44 vendors who attended the farmers market, 40 (91 per cent) were contacted. Inclusion of their family members brought the total subjects to 82; of these, 22 (27 per cent) reported a characteristic illness on the day of the market. All had onset of symptoms between 8:30 and 10:30 am. Of those ill, nausea was reported by 16 and vomiting by 13. Other symptoms included headache (5), cramps (4), dizziness (3), and diarrhea (2). Duration of the illness ranged from 1-24 hou
