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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Variations in the metabolism and maturation of collagen after fluoride ingestion

| Biochimica et Biophysica Acta | Sharma YD. | 715(1):137-41.
It is concluded that fluoride, ingested in excessive amounts, increases the solubility and degradation of collagen and reduces the collagen biosynthesis and cross-links. Therefore, the matured tissue collagen fibers would be abnormal due to inadequate cross-linking.

Effect of sodium fluoride on collagen cross-link precursors.

| Toxicology Letters | Sharma YD. | 10(1):97-100.
NaF [sodium fluoride] produces abnormal collagen fibres which provide an abnormal environment for calcification. The formation of defective collagen fibres during fluoride poisoning may explain the development of neobone in fluorosis. NaF is suggested to interfere with maturation of collegen fibres by exerting an adverse effect on cross-link precursors.

Fluorosis in dairy cattle

| The Veterinary Record | Griffith-Jones W. | 100: 84-89.
In 1934 there was a report from the United States (Phillips and others) of chronic fluorosis in cattle resulting from the use of rock phosphate. In Great Britain fluorsis arising from atmospheric pollution was reported by Blackmore and others in 1948 and Burns and Allcroft in 1964. Most of the references in the literature reported cases occurring as a result of industrial contamination of herbage, drinking water with a high fluorine content, or experimentally fed sources of fluorine (usually sod

Toxicity of fluoride to diabetic rats

January - March 1997 | Fluoride | Priya CA, Anitha K, Mohan EM, Pillai KS, Murthy PB. | 30(1): 51-58.
Pathological findings of the present study also indicate toxicological magnification by fluoride in diabetic rats. Both diabetes and fluorosis are major disorders which affect several organ systems. It may be concluded from the present study that toxicity by fluoride is greater in diabetes.