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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Fluoride tooth paste: a cause of perioral dermatitis

May 1976 | Archives of Dermatology | Mellette JR, Aeling JL, Nuss DD. | 112:730-731.
Since its description in 1957 by Frumess and Lewis as a “light-sensitive seborrheid,” perioral dermatitis (PD) has continued to be a perplexing entity. (1) Many causes have been postulated, including sunlight sensitivity, birth control pills, emotional stress, fluorinated steroid creams, Candida albicans, and rosacea. We have gathered clinical and historical data implicating fluoride dentrifices as an important etiologic factor in this dermatosis. The following two cases support this obse