Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Fluoride Metabolism in Pregnant Women: A Narrative Review of the Literature.

April 2, 2022 | Metabolites | Castiblanco-Rubio GA, Martinez-Mier EA. | 12(4):324.
(This article belongs to the Special Issue Fluoride Metabolism and the Effects of Fluoride on Metabolic Pathways and Diseases) Abstract Epidemiological studies use biomarkers of fluoride exposure in pregnant women as surrogate measures of fetal fluoride exposure; however, there is little understanding of how pregnancy affects fluoride metabolism and its biomarkers. This narrative review summarizes the changes of pregnancy that have the potential to impact fluoride’s absorpt

Fluoride tablet supplementation during pregnancy for caries immunity: a study of the offspring produced.

July 1, 1982 | American Journal of Obstetrics & Gynecology | Glenn FB, Glenn WD III, Duncan RC. | 43(5):560-564.
*Aided by a grant from the Children's Dental Research Sociey, Inc. References 1. Shen Y.W., Tawes D.R.Fluoride concentrations in the human placenta and maternal and cord blood.  Am. J. Obstet. Gynecol. 1974; 119: 205 Scopus (56) - PubMed - Abstract - Full Text PDF - Google Scholar 2. Boller R.J. Fetal morphogenesis of the human dentition. J. Dent. Child. 1964; 21: 67.  Google Schola 3. Burdi A., Superstine J. Development correlations of the deciduous and permanent teeth during t

Impact of Pharmacological Interventions in Expectant Mothers Resulting in Altered Mutans Streptococci Levels in their Children.

September-October 2015 | Pediatric Dentistry | Muthu MS, Ankita S, Renugalakshmi A, Richard K. | 37(5):422-8.
... The efficacy of postnatal interventions in expectant mothers for preventing dental caries and MS transmission in their children has been thoroughly studied18; however, data regarding the efficacy of prenatal interventions remain unclear. Therefore, the purpose of this paper was to provide a systematic review of the current literature assessing the efficacy of maternal administration of fluoride, chlorhexidine mouthrinses, and xylitol in altering the mutans streptococci levels in children.

Exposure to environmental neurotoxic substances and neurodevelopment in children from Latin America and the Caribbean.

January 2021 | Environmental Research | By José G.Dórea | 192:110199.
Introduction Environmental neurotoxicants are pollutants that can negatively affect many cellular metabolic-processes through different pathways: neuroendocrine/thyroid hormone disruption (Pb, methyl-Hg, organochlorines, and polychlorinated biphenyls-PCB), oxidative stress (Pb, methyl-Hg, organochlorines, and chlorpyrifos), dopamine dysfunction (Pb, methyl-Hg, As, chlorpyrifos, pyrethroids, and organochlorines) (Heyer and Meredith, 2017; Rock and Patisaul, 2018). Pistollato et al. (2020)

Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.

April 11, 2022 | Ecotoxicology and Environmental Safety | Han X, Tang Y, Zhang Y, Zhang J, Hu Z, Xu W, Xu S, Niu Q. | 236:113500.
1. Introduction Fluoride is widespread and unevenly distributed in the environment, and it can be rapidly absorbed into the body via water, food, and air (Johnston and Strobel, 2020). Fluoride consumption at the prescribed level is essential for human health, whereas excessive fluoride exposure is harmful to health. Groundwater, minerals, soil, household chemical products such as varnishes, gels, mouthwashes, and toothpaste are significant sources of fluoride exposure. Others include industrial

The oral microbiome: Role of key organisms and complex networks in oral health and disease.

October 2021 | Periodontol 2000 | Sedghi L, DiMassa V, Harrington A, Lynch SV, Kapila YL. | 87(1):107-131.
7.2. Toothpaste The effects of toothpaste on the oral microbiota have been investigated more thoroughly than the effects of toothbrushes. In the same study as previously described,33 the researchers also compared the oral and toothbrush microbiotas of participants who used either traditional Chinese medicine toothpaste or antibacterial toothpaste. While both types of toothpaste effectively reduced the numbers of a selection of pathogenic bacteria, they also suppressed oral S salivarius and L