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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Excessive iodine intake, water chemicals and endemic goitre in a Sudanese coastal area

September 2013 | Public Health Nutrition | Medani AM, Elnour AA, Saeed AM. | 16(9):1586-92.
Table 2 shows the correlation between various clinical indicators of thyroid function in schoolchildren and the concentration of water chemicals in Port Sudan. It indicates that thyroid hormones (T3 and T4) were poorly correlated with the concentration of water chemicals. TSH was significantly correlated with F– concentration (r=0.506, P=0.004) and inversely correlated with Ca2+ concentration (r=-0.506, P=0.004) and hardness (r=-0.506, P=0.004).

JNK and NADPH oxidase involved in fluoride-induced oxidative stress in BV-2 microglia cells.

August 29, 2013 | Mediators of Inflammation | Yan L, Liu S, Wang C, Wang F, Song Y, Yan N, Xi S, Liu Z, Sun G. | 2013:895975. doi: 10.1155/2013/895975.
Abstract Excessive fluoride may cause central nervous system (CNS) dysfunction, and oxidative stress is a recognized mode of action of fluoride toxicity. In CNS, activated microglial cells can release more reactive oxygen species (ROS), and NADPH oxidase (NOX) is the major enzyme for the production of extracellular superoxide in microglia. ROS have been characterized as an important secondary messenger and modulator for various mammalian intracellular signaling pathways, including the MAPK path