Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Sodium fluoride induces apoptosis through the downregulation of hypoxia-inducible factor-1a in primary cultured rat chondrocytes

February 2014 | International Journal of Molecular Medicine | Meng H, Zhang T, Liu W, Wang H, Wang C, Zhao Z, Liu N, Wang W. | 33(2):351-8.
Results of previous studies have shown that fluoride has a higher and special affinity for calcium in bone tissue, which could result in osteofluorosis (19,20). It has been reported that osteofluorosis may increase the severity of osteoarthritis (OA) characterized by progressive degeneration of articular cartilage (21,22). Chondrocyte apoptosis may be involved in the onset and development of osteoarthritic cartilage degeneration (23). Previously, chondrocytes were found to be responsible for the

Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease.

April 2007 | Endocrine Reviews | Chavassieux P, Seeman E, Delmas PD. | 28(2):151-64.
... Osteomalacia may be drug-induced (fluoride or etidronate) or the result of aluminum exposure in parenteral nutrition or hemodialysis. Clinical features are pain, fissures, and fractures, which may occur after minimal trauma (61) ... B. Abnormal mineral: fluorosis The effects of fluoride on bone tissue depend on the cumulative dose: at very low dose, less than 1.5 mg F/d, fluoride prevents the development of dental caries; at doses of about 23 mg F/d, fluoride was proposed in the treatm