Sodium fluoride induces apoptosis through the downregulation of hypoxia-inducible factor-1a in primary cultured rat chondrocytes
February 2014
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International Journal of Molecular Medicine
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Meng H, Zhang T, Liu W, Wang H, Wang C, Zhao Z, Liu N, Wang W.
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33(2):351-8.
Results of previous studies have shown that fluoride has a higher and special affinity for calcium in bone tissue, which could result in osteofluorosis (19,20). It has been reported that osteofluorosis may increase the severity of osteoarthritis (OA) characterized by progressive degeneration of articular cartilage (21,22). Chondrocyte apoptosis may be involved in the onset and development of osteoarthritic cartilage degeneration (23). Previously, chondrocytes were found to be responsible for the