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Effects of fluoride on bone in Finland. Histomorphometry of cadaver bone from low and high fluoride areas

The main histolological change induced by fluoride is the increase of osteoid volume… This increase in osteoid parameters was observed in our study already at fluoride concentrations above 1.5 ppm. . . .  Fluoridation of drinking water up to 1.2 ppm apparently does not pose a potential risk to bone provided the renal function is normal. . . . We should, however, recognize that it is difficult to give a strict value for a safe fluoride concentration in drinking water, because individual suscep