The effect of stannous fluoride and stannous chloride on inflammation
1968
|
Toxicology and Applied Pharmacology
|
Stone OJ, Willis CJ.
|
13: 332-38.
We believe that the metals and halogens that produce pustule along the scratch are damaging the body’s defenses against the mediators of inflammation and are therefore exaggerating the early cellular phase of inflammation… Dentrifices (toothpastes) are not made for prolonged contact with tissue; however, even brief exposure might influence preexisting oral pathology. Further clinical observations on the effects of fluoride dentrifices on oral inflammation are indicated.”