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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Effects of fluorine on calcium metabolism and bone growth in pigs

May 1953 | American Journal of Anatomy | Comar CL, Visek WJ, Lotz WE Rust JH. | 92(3):361-89.
Summary The interrelated effects of dietary fluorine and feed intake on bone growth, body growth, Ca45 behavior, bone pathology and feed utilization are demonstrated in young pigs. A fluorine level of 1000 ppm in the ration reduced the appetite and caused a decrease in bone growth, body growth, and feed required per unit of skeletal growth. There was an increase in feed required per unit weight gain. When animals were restricted to the same dietary intake, levels of 200 and 1000 ppm flu

The fluorine content in favorite foods of Japanese

January 1967 | Japanese Journal of Public Health | Okamura T, Matsuhisa T. | 14(1):41-47.
Summary The fluorine content of Japanese foods was determined and the daily intake of fluorine by the individual from the rural diet in the central Japan was estimated with different crop years. In 1958 the fluorine intake of a person was 4.38 mg daily in winter, and in 1965 was 11.13 mg. This increase was due to the yearly increase of the fluorine content of Japanese foods. The contents of fluorine of rice and ''miso", which are the mainstay of the diet in Japan, showed geographical correlat

Skeletal fluorosis in relation to drinking water, nutritional status and living habits in rural areas of Maharashtra, India

February 2014 | Journal of Environmental Science, Toxicology and Food Technology | Dhurvey V, Dhawas S. | 8(1):63-67
The present study was carried out during May 2010 to December 2011 in three villages which were randomly selected from Warora tehsil of Chandrapur district which is one of the endemic district of Maharashtra. . . . All the presently available ground water samples were collected and the mean fluoride concentration  was estimated by the ion analyser method, varied from 0.73 to 2.80 mg/L compared to the recommended  maximum permissible limit of 1.5 mg/L. As seen in Table 5 a high prevalence o

Sodium fluoride induces apoptosis through the downregulation of hypoxia-inducible factor-1a in primary cultured rat chondrocytes

February 2014 | International Journal of Molecular Medicine | Meng H, Zhang T, Liu W, Wang H, Wang C, Zhao Z, Liu N, Wang W. | 33(2):351-8.
Results of previous studies have shown that fluoride has a higher and special affinity for calcium in bone tissue, which could result in osteofluorosis (19,20). It has been reported that osteofluorosis may increase the severity of osteoarthritis (OA) characterized by progressive degeneration of articular cartilage (21,22). Chondrocyte apoptosis may be involved in the onset and development of osteoarthritic cartilage degeneration (23). Previously, chondrocytes were found to be responsible for the