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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Extended follow-up of cancer incidence in fluoride-exposed workers

May 19, 2004 | Journal of the National Cancer Institute | Grandjean P, Olsen JH. | 96(10):802-03.
Workers at the cryolite mill in Copenhagen, Denmark, are unique because of their exposure to high levels of fluoride dust and their virtual lack of exposure to other occupational toxicants or carcinogens (1,2). We previously reported the cancer morbidity from 1943 through 1987 for 422 male cryolite workers employed for more than 6 months at the mill from 1924 through 1961 (1). We observed excess incidences of primary cancer of the lungs and of urinary bladder tumors (including bladder papilloma)

Nail and bone surface as biomarkers for acute fluoride exposure in rats.

May-June 2004 | Journal of Analytical Toxicology | Buzalaf MA, Caroselli EE, Cardoso de Oliveira R, Granjeiro JM, Whitford GM. | 8(4):249-52.
Finally, in our 48-h study, we found that bone surface fluo- ride concentrations increased sooner than those in the nails and that they did not decline as they did in nails. This suggests that fluoride accumulation on the periosteal surface of the femur is faster and less likely to change as a function of time. For these reasons, we believe that this region of the femur is probably a better biomarker to confirm exposure to large doses of fluoride.