Effects of fluoride on bone in Finland. Histomorphometry of cadaver bone from low and high fluoride areas
April 1985
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Acta Orthopaedica Scandinavica
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Arnala I, Alhava EM, Kauranen P.
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;56(2):161-6.
The main histolological change induced by fluoride is the increase of osteoid volume… This increase in osteoid parameters was observed in our study already at fluoride concentrations above 1.5 ppm. . . . Fluoridation of drinking water up to 1.2 ppm apparently does not pose a potential risk to bone provided the renal function is normal. . . . We should, however, recognize that it is difficult to give a strict value for a safe fluoride concentration in drinking water, because individual suscep