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Allergic reactions from fluorides

In a discussion of drug allergy it is necessary to distinguish between intolerance and allergy to drugs. One represents intoxication, the other is characterized by wheal formation, eosinophilia and other features of an allergic reaction. Gastric irritation, for instance, or acne from iodides or bromides represent intolerance to these drugs due to increased susceptibility of certain tissue; it cannot be associated with allergic reaction. A discussion of allergy to halogens must establish chara