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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Fluoride metabolism in uremia

1973 | Transactions of the American Society of Artifical Internal Organs | Nielsen E, Solomon N, Goodwin NJ, Siddhivarn N, Galonsky R, Taves D, Friedman EA. | 19:450-5.
Summary These data show that: 1. During a 2 year period, the chronic use of fluoridated water in patients undergoing maintenance hemodialysis was associated with a rise in serum phosphatase in 10 of 20 patients studied and an increased radiographic incidence of osteodystrophy. 2. Eight long-term hemodialysis patients manifested no radiographic evidence of osteodystrophy during their first 2 to 6 years of hemodialysis, and one of these patients currently has a negative bone survey, 9 years aft

Effects of dialysate calcium and fluoride on bone disease during regular hemodialysis

February 1972 | Journal of laboratory and clinical medicine | Jowsey J, Johnson WJ, Taves DR, Kelly PJ. | 79(2):204-14.
Increased osteoid is typically found in fluorosis, hence, ascribing our findings to an F effect seems reasonable. There are several possible reasons for F causing increased osteoid. In vivo, excessive F can result in increased bone production and failure of mineralization… It may be noteworthy that 4 of the 5 patients with the most disabling symptoms of bone pain, muscle weakness, wasting and multiple spontaneous fractures were exposed to high-F dialysate. This would suggest that prolonged exp