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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Systematic review of water fluoridation.

September 12, 2000 | BMJ | McDonagh MS, Whiting PF, Wilson PM, Sutton AJ, Chestnutt I, Cooper J, Misso K, Bradley M, Treasure E, Kleijnen J. | 321:855.
Objective: To review the safety and efficacy of fluoridation of drinking water. Design: Search of 25 electronic databases and world wide web. Relevant journals hand searched; further information requested from authors. Inclusion criteria were a predefined hierarchy of evidence and objectives. Study validity was assessed with checklists. Two reviewers independently screened sources, extracted data, and assessed validity. Main outcome measures: Decayed, missing, and filled primary/permanent teet

Increased fluoride content in the femur growth plate and cortical bone of uremic rats

September 2000 | Pediatric Nephrology | Mathias RS, Amin U, Mathews CH, Denbesten P. | 14(10-11):935-9
In summary, we demonstrate an increased F– content in the growth plate region of the femur at 4 weeks and 8 weeks, and in cortical bone at 8 weeks, in rats with experimental CRI. We hypothesize that elevated serum F– levels might contribute to the disturbances in mineral ion homeostasis that are observed in patients with CRI. This is of particular concern since the incidence of dental fluorosis has increased due to increased F– uptake from multiple fluoridated sources [24]. The ubiquitous