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Developmental toxicity evaluation of sodium fluoride administered to rats and rabbits in drinking water.

The authors comments on the Embryo–fetal effects on rats: ... Although there were no significant pairwise effects from sodium fluoride administration, the percentage of litters with one or more external malformed fetuses, the percentage of externally malformed fetuses per litter and the percentage of skeletally malformed fetuses per liter, exhibited increasing trends with increasing dose of sodium fluoride (Table 2 and 3). No significant effect were noted in the prevalence of variations in