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Fluorine in the aetiology of endemic goitre

MANY different factors leading to relative or absolute deficiency of iodine may cause changes in the thyroid gland. May (1935) found that the administration of fluorine to rats produced hypoplasia of the thyroid epithelium with altered staining reaction of the colloid. Having experimented with over 800 patients, he advocated internal fluorine therapy in the treatment of toxic goitre. The evidence of alteration in thyroid structure in the experimental production of chronic fluorosis in animals is