OBJECTIVE: The present study focuses on serum testosterone concentrations in patients with skeletal fluorosis, in order to assess the hormonal status in fluoride toxicity. METHODS: Serum testosterones were compared for patients afflicted with skeletal fluorosis (n = 30) and healthy males consuming water containing less than 1 ppm fluoride (Control 1, n = 26) and a second category of controls (Control 2, n = 16): individuals living in the same house as the patients and consuming same water as
The authors comments on the Embryo–fetal effects on rats:
... Although there were no significant pairwise effects from sodium fluoride administration, the percentage of litters with one or more external malformed fetuses, the percentage of externally malformed fetuses per litter and the percentage of skeletally malformed fetuses per liter, exhibited increasing trends with increasing dose of sodium fluoride (Table 2 and 3). No significant effect were noted in the prevalence of variations in
