Tissue response of gastric mucosa after ingestion of fluoride
June 24, 1989
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British Medical Journal
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Spak CJ, Sjöstedt S, Eleborg L, Veress B, Perbeck L, Ekstrand J.
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298(6689):1686-7.
Fluoride has been used successfully to prevent dental caries and has also been used to treat osteoporosis. Doses of sodium fluoride of about 50 mg a day have long term beneficial effects on the mineral content of bone and the incidence of fracture. (1) These doses, however, have resulted in gastric disturbances in some patients. (1, 2) We studied the response of the gastric mucosa after a single dose of fluoride.
Methods and results
Twelve healthy volunteers (age range 22-45, four men and