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Functional state of thyroid under extended exposure to fluorides

The issue of specific effect of fluorine on the thyroid in humans remains debatable. There is no doubt, however, that cases of experimental fluorosis are characterized by specific toxicity of fluorine to the thyroid. The hypoactivity of thyroid epithelium is observed, the destructive changes in the follicular cells increasing with the increased intoxication time (1, 9). According to some authors (6, 12, 13), no specific fluorine toxicity to the thyroid is observed in fluorine-endemic areas