... Histological analysis of cerebral cortex, cerebellum and hippocampus of control and fluoride-treated rats are depicted in Figs. 1,2, and 3. The histopathological changes in both doses of fluoride groups were more or less the same but differed only in their degree of severity. The cerebral cortex of control rats showed normal morphology with intact neuron and cytoplasm (Fig. 1). Fluoride treatment resulted in necrosis, which is depicted by hyperchromasia and disintegrated cytoplasm. Cytoplasm
The present paper identifies different expressed proteins in the brains of rats under the treatment of high fluoride, low iodine, and both together compared to controls, in order to better understand the changes in functional proteins to gain insight into the mechanisms of high fluoride and low iodine. The proteins that were found to be significantly regulated (up-regulated and down-regulated) included guanine nucleotide-binding proteins (G proteins), synaptotagmin I, lactate dehydrogenase A (L
