On the grounds of the results obtained during our experiments F compounds are able to produce certain changes in chromosomes from somatic cells of animals treated in vivo by them… Most of the aberrations observed in the case of bone marrow cells were chromatid-type aberrations… [W]e entertain the opinion that the main damage to chromosomes during our experiments with F compounds also took part during the S-phase… [T]hese data enable us to consider as sufficiently established the conclusion
Introduction
Although widespread in occurrence, fluorine (as fluoride ion, F-) does not have any known physiological requirement. It is generally accepted, however, that long term over-intake of fluoride may cause skeletal as well as dental fluorosis. Many studies on other toxic effects of fluoride have been made, including whether it alters human genetic material and ultimately leads to more serious harm. (1) At present, various test systems and methods have been developed to detect fluoride
