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Micronucleus and sister chromatid exchange frequency in endemic fluorosis

Introduction Although widespread in occurrence, fluorine (as fluoride ion, F-) does not have any known physiological requirement. It is generally accepted, however, that long term over-intake of fluoride may cause skeletal as well as dental fluorosis. Many studies on other toxic effects of fluoride have been made, including whether it alters human genetic material and ultimately leads to more serious harm. (1) At present, various test systems and methods have been developed to detect fluoride

Effect of sodium fluoride on tumor growth

Recently a report (1) from this laboratory indicated that NaBr in relatively low concentrations accelerated the growth of mouse and egg cultivated tumor tissue. This result occurred when the drug was introduced by way of the drinking water in mice, by injection over the embryonic membranes of eggs inoculated with tumor tissue, and when added to tumor tissue suspensions before implantation into eggs or mice. Preliminary tests with NaI and NaF give evidence that low levels of these halides also ac