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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Experimental fluorosis in rats: NaF induced changes of bone and bone marrow

April 1983 | Fluoride | Bely M. | 16(2):106-11.
The results of our experiments suggest that increased doses of NaF cause more extensive osteosclerosis due to the decrease in number and/or activity of osteoclasts. Therefore oateosclerosis is caused primarily, not by increased bone formation but, by the inhibition of bone resorption. This view is supported by the fact that fluoride inhibits acid phosphatase activity more than alkaline phosphatase (6). The acid phosphatase activity of osteoclasts is of greater inteneiry than that of osteoblasts

Perioral dermatitis

Spring 1983 | Journal of the Association of Military Dermatologists | Mellette JR, Aeling JL, Nuss DD. | 9(1):3-8.
Since its description in 1957 by Frumess and Lewis (1) as a "light-sensitive seborrheid," perioral dermatitis (PD) has been a perplexing entity. It characteristically presents as a chronic eruption consisting of papules and pustules that develop on irregular areas of erythema and edema. the eruption is most prominent in the perioral area, but occasionally it extends symmetrically along the nasolabial folds and lateral canthus. An eczematous and scaly component associated with burning and itching

In vitro inhibition of testosterone synthesis in the presence of fluoride ions

1983 | IRCS Medical Science | Kanwar KC, Vig PS, Kalla NR. | 11: 813-814.
A marked fall (p < 0.01) in the testosterone production was recorded at a fluoride concentration of 100 ppm and testosterone synthesis was maximally inhibited (p < 0.01) at 200 ppm. There was a noticeable, though marginal, inhibition in testosterone synthesis even at 10 ppm fluoride concentration. From 1 ppm to 200 ppm, the degree of inhibition of testosterone synthesis seems to be dependent on fluoride concentration.