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Studies of relationships between the polymorphism of COMT gene and plasma proteomic profiling and children’s intelligence in high fluoride areas

Fluoride (F) widely exists in environment with a significant increase in body burden accumulation in recent years. Internal exposure to F due to diet including food, water, fluoride-containing dental products like toothpaste and fluoride supplements, is extensively researched. Additionally, industrial pollution and coal burning have also been reported to be major sources of internal F exposure, especially in China. It is known that excessive fluoride intake over a long period of time may resu

Pathological changes in the tissues of rats (albino) and monkeys (macaca radiata) in fluorine toxicosis

From the photo-micrographs given here, it can be seen that fluorine seems to cause a selective destruction of the epithelium. The epithelium has been found to be considerably damaged in the stomach, duodenum, small intestine, lungs and thyroid. The loss or damage of the epithelium of the digestive tract would undoubtedly have an adverse effect on the functions of the tract. Such a circumstance has rather already been demonstrated (Wadhwani, 1953). It has been shown that, as a result of F ingesti

Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity

“While the small amount of AlF in the drinking water of rats required for neurotoxic effects is surprising, perhaps even more surprising are the neurotoxic results of NaF at the dose given in the present study [1.0 ppm F]... The results of the present study indicate that more intensive neuropathological evaluations of F effects on brain may prove to be of value... In summary, chronic administration of AlF and NaF in the drinking water of rats resulted in distinct morphological alterations in t