NaF [sodium fluoride] produces abnormal collagen fibres which provide an abnormal environment for calcification. The formation of defective collagen fibres during fluoride poisoning may explain the development of neobone in fluorosis. NaF is suggested to interfere with maturation of collegen fibres by exerting an adverse effect on cross-link precursors.
A.P. Tarinsky (4) revealed a 2-3 fold increase of symptoms of oligospermia and azoospermi a in male W¢rkers suffering from industrial fluorosis compared with healthy men o f the same age. Tokar (5, 6) found an association between fluorosis and hypogonadism. These data made it necessary to study the changes of synthetic processes in the testes of mice in experimental fluorosis. A total scintillation method of probe computing on the counter revealed certain shifts of RNA and prote in metabolism i
In "Indian basket weavers exposed to fluoride, it was observed that the much used left arm and wrist were particularly susceptible to fluorotic exostosis... [T]he areas suffering repeated or constant stress or trauma, and as a result requiring ongoing repair, may be areas of increased circulation and metabolism and, as a consequence, increased deposition of fluorides.
Artificially fluoridated drinking water is supplied throughout the world as a mass-prophylactic against dental caries. No data are available, however, on the transfer of fluoride from maternal plasma to breast milk. We have therefore compared the fluoride concentration in the plasma and breast milk of nursing mothers after an oral dose of fluoride.
Subjects and Methods
Five mothers aged 27-36 years were given fluoride by mouth on the third postpartum day. A dose of 1.5 mg was given as an a
