Integrative transcriptome and metabolome analysis of fluoride exposure induced developmental neurotoxicity in mouse brain.
January 1, 2024
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Ecotoxicology and Environmental Safety
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Zhu X, Zhang S, Liu X, Li H, Zhu X, Zhang J, Wang X, Zhang M.
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269:115752.
5. Conclusion
First, fluoride exposure during pregnancy and lactation may cause neurodevelopmental disorders in the offspring mice, including abnormal expression of genes related to synaptic function, and aneurotransmitters’ accumulation; the magnitude and spectrum of response to fluoride exposure in parents and offspring are significantly different.
Second, in mice exposed to fluoride during gestation and lactation, metabolic accumulation of choline and arachidonic acid and their derivati