Neuroligin-3 activates Akt-dependent Nrf2 cascade to protect osteoblasts from oxidative stress.
November 1, 2023
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Free Radical Biology and Medicine
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Fan J-B, Yuan K, Zhu X-H, Cui S-Y, Yi H, Zhang W.
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208:1(807-819).
Introduction
Osteoblasts are derived from mesenchymal progenitor cells and are the main functional cells for bone formation [[1], [2], [3]]. They are responsible for the synthesis, secretion and mineralization of bone matrix and can secrete various bioactive substances for bone formation and reconstruction [[1], [2], [3]]. In the pathogenesis of osteoporosis, uncontrolled reactive oxygen species (ROS) production and excessive oxidative injury will lead to significant damage and death of osteo