Abstract
Background: Topical fluoride application in moderate and high-risk individuals and in those living in low-fluoride communities has been a common practice by dental professionals.
Objectives: The objective of this study was to assess fluoride concentration available in saliva after a professional 2% sodium fluoride solution application (9000 ppm), and the duration of its availability to have an evidence-based practice for application.
Materials and Methods: Two percent sod
Background
A novel sodium fluoride toothpaste containing lactate ion and polyvinylmethylether-maleic anhydride has been developed to promote enamel remineralisation and resistance to demineralisation. In this in situ study, we compared this toothpaste (‘Test’) with a stannous fluoride-zinc citrate (SnF2-Zn) toothpaste (‘Reference’) (both 1100–1150 ppm fluoride) and a fluoride-free toothpaste (‘Placebo’) using an enamel dental erosion-rehardening model.
Methods
In each phas
The example of sodium fluoride (NaF) clearly demonstrates an instance where increasing bone mass while altering maturation can negatively affect drug efficacy. NaF was a promising osteoporosis treatment because it increased BMD.5 However, it became evident that the treated patients were at increased risk of fracture,6, 7 which was later attributed to NaF-induced aberrant mineralization.8 Had there been a preclinical model to assess the effect of NaF on maturation, it is likely that these f
First Page of Study
Since the investigation of Black an,d McKay in 1916 into the problem of mottled enamel, and the definite association of this anomaly with the fluorine content of drinking waters by Churchill (1931, 1932), the matter of fluorine intoxication has been studied in detail by different workers in various parts of the World. It has been shown that this mottling of the enamel occurs only if the fluorine content of the water is above 2 to 3 mg. per litre (Smith and Smith, 1932) or, a
FIRST PAGE OF PAPER
All animal tissues and plants contain fluorine in very small amounts. It is found in soils, rocks and water.
No convincing evidence has been as yet produced to show that it performs any useful function in animal nutrition, or that it is essential for animal metabolism. During the past 15 years, however, evidence has been accumulated to show that the prolonged ingestion of abnormal quantities produces a chronic toxic state, the earliest visible sign of which is called 'mot
