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Evaluation of fluoride-induced oxidative stress in rat brain: a multigeneration study.

... Histological analysis of cerebral cortex, cerebellum and hippocampus of control and fluoride-treated rats are depicted in Figs. 1,2, and 3. The histopathological changes in both doses of fluoride groups were more or less the same but differed only in their degree of severity. The cerebral cortex of control rats showed normal morphology with intact neuron and cytoplasm (Fig. 1). Fluoride treatment resulted in necrosis, which is depicted by hyperchromasia and disintegrated cytoplasm. Cytoplasm