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Proteomic analysis of brain proteins of rats exposed to high fluoride and low iodine.

The present paper identifies different expressed proteins in the brains of rats under the treatment of high fluoride, low iodine, and both together compared to controls, in order to better understand the changes in functional proteins to gain insight into the mechanisms of high fluoride and low iodine. The proteins that were found to be significantly regulated (up-regulated and down-regulated) included guanine nucleotide-binding proteins (G proteins), synaptotagmin I, lactate dehydrogenase A (L