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Fluoride-induced apoptosis in non-skeletal tissues of experimental animals: A systematic review and meta-analysis.

1. Introduction ... Apoptosis is a highly regulated and programmed cell death characterized by specific biochemical and morphological features that culminate in cellular shrinkage to apoptotic bodies that are engulfed by neighboring macrophages [[12]]. This occurs without an accompanying inflammatory response. Characterized morphological changes accompanying apoptosis include cleavage of cytoskeletal filament fibers, cell cytoplasm, and nucleus condense, DNA fragmentation by the action of end