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Discussion
We used data from a prospective pregnancy and birth cohort to compare the associations between fluoride exposures during different developmental windows and preschool aged children’s intellectual abilities. The GEE method advances our understanding of early-life fluoride neurotoxicity by formally comparing strength of associations across windows of exposure. The strongest association between fluoride and child IQ was observed between standardized MUF and age-normed PIQ (B = -2.36
Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
References
Aghaei M, Derakhshani R, Raoof M, Dehghani M, Mahvi AH (2015a) Effect of fluoride in drinking water on birth height and weight: an ecological study in Kerman Province Zarand County, Iran. Fluoride 48:160–168
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Aghaei M, Karimzade S, Yaseri M, Khorsandi H, Zolfi E, Mahvi
"... significant differences were found in U-tAs and U-F- levels between males and females. Specifically, urine from women contained on average less tAs (41.5 vs 59.4 ng/mL) and F- (1.9 vs 2.4 µg/mL) than urine of men.
"Notably, both signs of dental fluorosis and skin lesions typical of the chronic iAs exposure (keratosis and changes in pigmentation) were observed in several participants during the introductory medical exam (unpublished data). Previously, dental fluorosis was reported for 80
Level 3 at
https://ec.europa.eu/health/scientific_committees/opinions_layman/fluoridation/en/l-3/index.htm#0
The texts in Level 3 are directy quoted from:
Source & ©: SCHER Critical review of any new evidence on the hazard profile, health effects, and human exposure to fluoride and the fluoridating agents of drinking water More...
1 Introduction
Background
Fluoride is not considered to be essential for human growth and development but it is considered to be beneficial in the
