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Revisiting Fluoride in the Twenty-First Century: Safety and Efficacy Considerations.

Conclusions In this manuscript, we present a simple graphical plot/tabular tool which allows clinicians to gauge the overall exposure of their patients to fluoride-containing products with respect to both acute and chronic toxicities. This tool will undoubtedly also assist clinicians who wish to discuss these issues with adult patients, and parents of child patients, about fluoride anion, fluoride adducts, and their potential, albeit very unlikely, toxic effects. After over 100 years of discov