References
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References
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Discussion
The principal findings of this study were that enflurane affected performance on these tests in a manner qualitatively similar to, though quantitatively different from, halothane. Since the minimum alveolar concentration (MAC), an index of anesthetic potency, is about twice as high for enflurane as for halothane, comparison of the same trace amounts of each agent would be expected to show a smaller effect of enflurane. This was found in these studies. In addition, the end-expired c
READERS of this periodical were probably intrigued when, in 1971, almost an entire issue was devoted to studies in volunteers of a new anesthetic, isoflurane (Forane), a novel and useful editorial departure. Since then, a series of reports in the Journal has cast further light on some of the more arcane properties of this heavily fluorinated ether. Why then is this well-studied drug not yet available for clinical use, while its isomer, enflurane, has been accorded official approval? How and when
Excerpt
Introduction
According to experimental and field studies, exposure to more than 500 ppm of nitrous oxide(N 2O) and more than 15 ppm of haJothane and enflurane can cause performance impairment in neurobehavioral exammations (Bruce and Bach 1975, 1976; Smith and Shirley 1978; Allison et al. 1979; Edling 1980; Mahoney et al. 1988. Control of exposure to anesthetic gases has received increased attention since the mid-1970s, when scavenging devices were fitted on anesthesia machines to
