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Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.

1. Introduction Fluoride is widespread and unevenly distributed in the environment, and it can be rapidly absorbed into the body via water, food, and air (Johnston and Strobel, 2020). Fluoride consumption at the prescribed level is essential for human health, whereas excessive fluoride exposure is harmful to health. Groundwater, minerals, soil, household chemical products such as varnishes, gels, mouthwashes, and toothpaste are significant sources of fluoride exposure. Others include industrial

A Systematic Review and Meta-Analysis of the Relationship Between the Severity of Dental Fluorosis and Fluoride Biomarkers in Endemic Areas.

References Wei W, Pang S, Sun D (2019) The pathogenesis of endemic fluorosis: Research progress in the last 5 years. J Cell Mol Med 23:2333–2342. https://doi.org/10.1111/jcmm.14185 CAS  Article  PubMed  PubMed Central  Google Scholar Patil MM, Lakhkar BB, Patil SS (2018) Curse of Fluorosis. Indian J Pediatr 85:375–383. https://doi.org/10.1007/s12098-017-2574-z CAS  Article  PubMed  Google Scholar Kurdi MS (2016) Chronic fluorosis: The disease and its a

Fluoride Metabolism in Pregnant Women: A Narrative Review of the Literature.

(This article belongs to the Special Issue Fluoride Metabolism and the Effects of Fluoride on Metabolic Pathways and Diseases) Abstract Epidemiological studies use biomarkers of fluoride exposure in pregnant women as surrogate measures of fetal fluoride exposure; however, there is little understanding of how pregnancy affects fluoride metabolism and its biomarkers. This narrative review summarizes the changes of pregnancy that have the potential to impact fluoride’s absorpt