Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.
April 11, 2022
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Ecotoxicology and Environmental Safety
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Han X, Tang Y, Zhang Y, Zhang J, Hu Z, Xu W, Xu S, Niu Q.
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236:113500.
1. Introduction
Fluoride is widespread and unevenly distributed in the environment, and it can be rapidly absorbed into the body via water, food, and air (Johnston and Strobel, 2020). Fluoride consumption at the prescribed level is essential for human health, whereas excessive fluoride exposure is harmful to health. Groundwater, minerals, soil, household chemical products such as varnishes, gels, mouthwashes, and toothpaste are significant sources of fluoride exposure. Others include industrial