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1. Introduction
Drinking water sources in the Rift Valley of Ethiopia contain fluoride (F) levels exceeding the World Health Organization (WHO) limit of 1.5 mg/L [1,2]. As a consequence, many people living in the region are severely affected by fluorosis [2,3,4,5,6,7,8]. In serious cases, dental fluorosis is manifested as brown mottling of the enamel and results in overall yellowing of the teeth with erosion of the enamel [2,8]. Skeletal fluorosis occurs when there is a high degree
Introduction
Fluorine is a necessary trace element for the normal development of human organs, but long-term exposure of fluorine will result a fluorosis [1,2]. Appropriate amount of fluoride has positive effects on teeth and bones, but long-term excessive intake can cause severe damage [3], leading to dental fluorosis and skeletal fluorosis [[4], [5], [6], [7]]. Patients with skeletal fluorosis display multiple bone lesions, such as osteoporosis, osteosclerosis, calcification of ligament
Data Availability
The datasets generated during and/or analyzed during the current study are not publicly available due to our research continues, such as exploring the mechanism of up regulation of HuR caused by fluorine. Hence, our original data will not be public temporarily. [REASON(S) WHY DATA ARE NOT PUBLIC] but are available from the corresponding author on reasonable request.
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Buzalaf MAR (2018) Review of fluoride intake and appropriateness of
