Effect of fluoride on the respiration rate of rat cardiac mitochondria.
July-September 2009
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Fluoride
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Pacauskiene I, Kopustinskiene D, Paipaliene P, Sadzeviciene R.
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42(3):198–202.
... In summary, NaF at concentrations of 5, 10, and 50 µM had no effect on the State 3 respiration rate of mitochondria oxidizing succinate or pyruvate + malate. However, NaF concentrations of 7.5, 15, and 25 mM resulted in a reproducible decrease in the oxidation rate of the succinate in dose-dependent manner. Since topical application of F-containing dental products can lead to accumulation of F in the oral cavity, in some cases at fairly high concentrations (16), such procedures run the risk