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The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Weakened interaction of ATG14 and the SNARE complex blocks autophagosome-lysosome fusion contributes to fluoride-induced developmental neurotoxicity.

December 22, 2021 | Ecotoxicology and Environmental Safety | Zhang Y, Han X, Tang Y, Zhang J, Hu Z, Xu W, Yao P, Niu Q. | [Epub ahead of print]. 230:113108 (2022).
Highlights NaF induced autophagosome-lysosome fusion blockage. NaF weakened the interaction of ATG14 and SNARE complex. ATG14 regulates the SNARE complex in NaF-induced developmental neurotoxicity. ATG14 upregulation restored autophagosome-lysosome fusion and autophagic flux. ATG14 upregulation protects against developmental fluoride neurotoxicity. Fluoride is capable of inducing developmental neurotoxicity, but the mechanisms involved remain unclear. We aimed to explor