The effect of fluoride on enamel and dentin formation in the uremic rat incisor
November 2008
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Pediatric Nephrology
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Lyaruu DM, Bronckers AL, Santos F, Mathias R, DenBesten P.
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23(11):1973-9
In summary, these studies show that tooth development is disturbed under uremic conditions. The effects of uremia are primarily in the dentin but also occur in enamel, resulting in hypoplasia and pitting of the enamel surface. The crown portion of human central incisors (the most aesthetically visible teeth) forms up to approximately 4 years of age, with the second permanent molars forming by about 8 years of age. Therefore, children who present with renal insufficiency before the age of 8 years