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Human cultured IMR-32 neuronal-like and U87 glial-like cells have different patterns of toxicity under fluoride exposure.

When comparing the F-induced toxicity on neurons and glial cells, it is important to highlight that most studies have used neurons and only two have investigate de glial cells behavior after F exposure [21, 36]. The effect of F on neuronal cell viability is inconsistent across the studies with doses ranging from 18.09 ?g/mL to 36.18 ?g/mL while glia/astrocytes seems to shown decreased cell viability above 19 ?g/mL. As our study is the first one to compare both types of cells facing the same para