Exposure to Fluoride induces apoptosis in liver of ducks by regulating Cyt-C/Caspase 3/9 signaling pathway.
August 16, 2021
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Ecotoxicology and Environmental Safety
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Ouyang Z, Yang B, Yi J, Zhu S, Lu S, Liu Y, Li Y, Li Y, Mehmood K, Hussain R, Ijaz M, Guo J, Tang Z, Li Y, Zhang H.
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224:112662.
Highlights
Long-term exposure NaF induced hepatotoxicity in ducks.
NaF exposure caused liver granule and vacuolar degeneration observed by histological analysis.
The mechanism of NaF exposure on hepatotoxicity involving activating autophagy and apoptosis.
Cyt-C/Caspase 3/9 signaling pathway activation target cell death.
Abstract
Fluorine being a well-known and essential element for normal physiological functions of tissues of different organisms is frequ