References
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Alt?nta? A, Fidanc? UR, Sel T, Duru Ö, Ba?satan A (2000) Do?al ve endüstriyel floro
The example of sodium fluoride (NaF) clearly demonstrates an instance where increasing bone mass while altering maturation can negatively affect drug efficacy. NaF was a promising osteoporosis treatment because it increased BMD.5 However, it became evident that the treated patients were at increased risk of fracture,6, 7 which was later attributed to NaF-induced aberrant mineralization.8 Had there been a preclinical model to assess the effect of NaF on maturation, it is likely that these f
First Page of Study
Since the investigation of Black an,d McKay in 1916 into the problem of mottled enamel, and the definite association of this anomaly with the fluorine content of drinking waters by Churchill (1931, 1932), the matter of fluorine intoxication has been studied in detail by different workers in various parts of the World. It has been shown that this mottling of the enamel occurs only if the fluorine content of the water is above 2 to 3 mg. per litre (Smith and Smith, 1932) or, a
Letter
Since it has been established that the dental disease in man known as "mottled enamel" is due to the drinking of water containing fluorine, the removal of fluorides by filtration has become an important problem.
I have found that a contact filter 15 cm high, made of river sand passing a screen 60 to the inch, to which has been added 2 per cent. by weight of powdered aluminium, will remove the fluoride from a solution containing 30 parts per million of sodium fluoride. The absence of f
FIRST PAGE OF PAPER
All animal tissues and plants contain fluorine in very small amounts. It is found in soils, rocks and water.
No convincing evidence has been as yet produced to show that it performs any useful function in animal nutrition, or that it is essential for animal metabolism. During the past 15 years, however, evidence has been accumulated to show that the prolonged ingestion of abnormal quantities produces a chronic toxic state, the earliest visible sign of which is called 'mot
